why the apoprofen decrease effect of asprin and both are NSAID
Ibuprofen inhibits COX temporarily.
Aspirin inhibits COX permanently.
If Ibuprofen is around, it will bind to COX. In the meantime, Aspirin gets excreted from the body. Now, the ibuprofen gets excreted, and voila, COX is fine. This is competitive. The importance is in the platelets, because usually, the cell can just make more COX to overcome Aspirin. But, platelets cannot make more COX. So, if COX is permanently inhibited by Aspirin, that platelet is as good as dead - the anticoagulant effect of Aspirin. If COX is temporarily inhibited by ibuprofen, that platelet is temporarily out of commision, but when Ibuprofen leaves, platelet works fine.
are you sure
they both thin the blood so it would be more logical for them to potentiate each other.
I think U mean "Ibuprophen" which is an NSAID (non steroidal anti inflammatory drug). Aspirin is also a kind of NSAID.
Aspirin should NOT be taken in conjunction with (at the same time as) ibuprophen unless you are told by your doctor to do this. Taken together, they can cause an increase in stomach ulcers and blood clotting problems.
I hope this helps.
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