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health advisory Hospital Doctor Yu 2007-11-8 19:09:43

Answers:

Signal transducers and activators of transcription (STATs):

STAT5 belongs to a small family of transcription factors with dual functions. The seven signal transducers and activators of transcription (STAT) act as signaling components between the plasma membrane and the nucleus, and as transcription factors with specific DNA binding ability in the nucleus. STAT5 regulates the expression of genes, which determine important cellular phenotypes. It can promote proliferation and inhibit apoptosis, but is also involved in the regulation of differentiation between specific gene expression. STAT5 can also contribute to the transformed phenotype. In many leukemias and some solid tumors, STAT5 is constitutively activated through receptors or receptor associated tyrosine kinases and contributes to the survival and the proliferation of malignant cells. STAT5 activity appears to be limiting for these phenotypes.

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signal transduction in LV hypertrophy and HF utilizes STAT protiens as2 ry messengers.

Role of STAT proteines in meditating angll autocrine loop , by activating angiotensinogen promoter, in LVH and HF and in inducing cardiac apaptosis and fibrosis through the inducation of TGF-B these results may pave the way to use inhibitors of STAT proteins phosphorylation to interrupt these cardiac pathological processes.

and i think that there is no other thing in this world like stat5(i might be wrong)

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