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health advisory Hospital Diseases 2007-11-12 17:56:02

Answer:

Acute intermittent porphyria (AIP) is a group of diseases involving defects in heme metabolism. AIP manifests itself by abdomen pain, neuropathies, and constipation, but, unlike most types of porphyria, patients with AIP do not have a rash.

Although patients with acute attacks always have elevations of porphobilinogen and ALA, how this leads to the symptomatic disease is still unclear because most patients with the genetic defect have excessive porphyrin secretion but no symptoms.

The treatment goal for acute attacks of porphyria is to decrease heme synthesis and reduce the production of porphyrin precursors.

High doses of glucose (400 g/d) can inhibit heme synthesis and are useful for treatment of mild attacks.

People experiencing severe attacks, especially those with severe neurologic symptoms, should be treated with hematin in a dose of 4 mg/kg/d for 4 days.

Pain control is best achieved with narcotics. Laxatives and stool softeners should be administered with the narcotics to avert exacerbating existing constipation.

Treat seizures with Neurontin. Most classic antiseizure medicines can lead to acute porphyria attacks.

Diet: The patient should receive a high-carbohydrate diet during the attack. If the patient is unable to eat, intravenous glucose should be administered. Between attacks, eating a balanced diet is more important than eating one rich in glucose.

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I think you mean porphyria. Here's a good site to go to:

www.porphyriafoundation.com

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Joint pains that come & go. Suggest that you visit a homoeopath who will be able to help you. Go to http://www.homeopathy-soh.org/ to find a practitioner in your area. Don't start on drugs as before you know it you'll be on 6 or so with all the side effects.

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I think you mean acute intermittent porphyria - have a look:

http://en.wikipedia.org/wiki/acute_inter...

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